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| Cytochrome
c oxidase present in Mitochondria have the
ability to absorb OsseoPulse photons and convert
this EMF energy into chemical energy (ATP)4. |
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| The
wounded tissue and bone around the implant
is ischemic and hematopoetic. Precursor cells
and fibroblasts have decreased ATP and decreased
metabolism. OsseoPulse™ treatment delivers
energy to the cells directly to increase production
of ATP which accelerates wound healing and
bone formation. |
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| 4. |
JT Eells et al
Mitochondrial Signal Transduction in Accelerated
Wound and Retinal Healing by Near-Infrared Light
Therapy
Mitochondrion 2004; 4:559–567 |
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The documentation referred to below consists of articles
and abstracts published, or accepted for publication,
in scientific journals.
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Accelerated
Implant Stability After LED Photobiomodulation
Brawn P, Kwong-Hing
A, Boeriu S and Clokie CM
J Dent Res 87(Spec Iss B):2021, 2008
Study: This article examines the effect
of OsseoPulse™ treatment on implant stability, as
assessed by resonance frequency analysis. 35 patients
had 63 dental implants placed. 23 patients were treated
with the OsseoPulse™ for 21 days. All implants were
tested for primary stability with an Osstell Mentor™
at the time of implant placement, 14, 30, 60 and 90 days.
Conclusion: Patients treated
with the OsseoPulse™
demonstrated significantly (p<0.05) improved dental
implant stability at day 14, day 30 and day 60. There
was a 58% reduction in time required to achieve sufficient
stability to load implants compared to controls. These
results may suggest that OsseoPulse™
treatments may allow for more rapid integration of dental
implants and earlier loading.
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Combined New Technologies to Improve Dental Implant Success -- Quantitative Ultrasound Evaluation of NIR-LED Photobiomodulation
Bouquot J and Brawn P
Oral Surg Oral Med Oral Pathol Oral Radiol Endod.
2008; 106(3):e6
Background: Dental implants must be placed
in healthy bone for successful osteointegration and stability.
Low bone density (LBD) and ischemically damaged, desiccated
bone both have a poor ability to remodel and are, therefore,
contraindications for implants. Near-infrared light emitting
diode (NIR-LED) therapy or photobiomodulation has been
shown in cultured cells and animal models to stimulate
bone healing and production.
Study: 68 patients received 12 weeks
of OsseoPulse therapy to 294 sites of ischemic/low bone
density. Bone density/hydration improved by 44%, and
42% of sites returned to completely normal bone.
Conclusion: OsseoPulse therapy seems
to hold good potential for improving alveolar bone prior
to implant placement.
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Phototherapy promotes attachment
and subsequent proliferation of human osteoblast-like
cells
Khadra M, Kasem N,
and Brawn P
J Dent Res 87(Spec Iss B):3308, 2008
Study: The aim of the study was to investigate
the effect of OsseoPulse™ treatment on attachment
and proliferation of human osteoblast-like cells cultured
on titanium implant material. Cells derived from human
mandibular bone were exposed to OsseoPulse™ and
then seeded onto titanium discs. Non-exposed cultures
served as controls. Cell proliferation was determined
after staining by counting cells under a light microscope.
Furthermore, MTT analyses were also performed to determine
cellular attachment and proliferation. Conclusion:
In this cellular model the attachment and proliferation
of human osteoblast-like cells cultured on titanium
implant material was significantly enhanced (p <0.05)
after OsseoPulse™
treatment compared to controls.
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Accelerated Implant Stability After LED Photobiomodulation Treatment
Brawn P, Kwong-Hing A, Aptekar A
Clin Oral Implants Res 2007; 86(2):cii
Study: 15 Nobel Biocare Replace Select™
implants were placed and the OsseoPulse™
device was utilized by the patient on a daily basis, at
their home, for 21 days post operatively. Implants were
tested for primarily stability with an Osstell Mentor™
over a period of 3 months.
The control untreated implants
from Day 14 to 30 presented a typical marked loss of
stability and did not reach the initial stability values
at 90 days. The OsseoPulse™
treated group experienced a slight loss at 14 days and
30 days, but exceeded initial stability values at Day
60 and 90.
Conclusion: The accelerated implant
stability of the OsseoPulse™
treated implants compared to the untreated controls
may allow for faster healing and loading of implants
that under conventional treatment regimes.
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A histologic comparison of
light emitting diode phototherapy-treated hydroxyapatite-grafted
extraction sockets
Brawn P, Kwong-Hing A
Implant Dent 2007; 16(2):204-11
Case Study: After bilateral extraction
of periodontally involved lower molars an investigational
OsseoPulse™ was used daily for 21 days on the treated
side after grafting both sockets with Hydroxyapatite (HA)
Osteograf LD300. Bone regeneration of the OsseoPulse™
treated and nontreated socket graft was compared. Histologic
evaluations showed enhanced bone formation and faster
particle resorption associated with the OsseoPulse™
treated socket graft compared with the untreated socket.
Conclusion: In this bilateral case
study the accelerated bone healing in the OsseoPulse™
treated HA socket graft may provide faster implant placement
compared to untreated treated socket grafts.
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Accelerated implant stability
in indirect sinus lifts with bone grafts using LED phototherapy
Kwong-Hing A, Brawn P
Proc FDI Sci 2006
Case Study: 4 bilateral implants were
placed in conjunction with indirect sinus lifts grafted
with Bio-Oss™ particulate. The implants were tested
for primary stability at initial placement and then weekly
for 4 weeks, and then at month 2 and 3. The
OsseoPulse™
treated implants increased stability compared to untreated
controls at all time periods and achieved stability
sufficient to load by the 2nd week, while the untreated
controls did not reach this level of stability until
after the 3rd Month.
Conclusion: The accelerated implant
stability of the OsseoPulse™
treated implants placed with simultaneous indirect sinus
lift and bone may provide faster implant stability compared
untreated implants. This may allow shorter treatment
times before prosthetics can be initiated.
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Biolux Research Ltd.